Drug Name

Celebrex (Celecoxib)

Drug Uses

Celecoxib is familiar for the relief of pain, fever, tumour, and tenderness caused by osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis. Celecoxib does not proscribe the progression of either paradigm of arthritis. It reduces simply the symptoms and signs of arthritis. Celecoxib has been approved for patients with familial FAP who demand not had their colons removed. Celebrex also is approved for the stand-in of acute pain and the trouble of menstrual cramps (initial dysmenorrhea).

How to use

The lowest personal property dose should be old for each patient. For the manipulation of osteoarthritis, the dose most often is 100 mg twice everyday or 200 mg as a single administer. For rheumatoid arthritis, the dose most often is 100 or 200 mg twice routine. For acute pain or menstrual cramps, the dispense is 400 mg as a single measure on the first day, followed by an additional 200 mg if needed, then 200mg twice constantly as needed. For FAP, the recommended prescribe is 400 mg twice continually.

Drug Class and Mechanism

Celecoxib is a nonsteroidal anti-frantic drug (NSAID) that is old to treat arthritis, labour, menstrual cramps, and colonic polyps. Prostaglandins are chemicals that are prominent contributors to the inflammation of arthritis that causes the discomposure, fever, swelling and tenderness. Celecoxib blocks the enzyme that makes prostaglandins (cyclooxygenase 2), resulting in diminish concentrations of prostaglandins. As a consequence, redness and its accompanying pain, fever, enlargement and tenderness are reduced. Celecoxib differs from other NSAIDs in that it causes less infection and ulceration of the stomach and intestine (at least with vest-pocket-term treatment) and does not one's oar in with the clotting of blood. NSAIDs press been found to fend the formation and reduce the bigness of polyps in patients with the genetic ailment, familial adenomatous polyposis (FAP). In FAP, patients exploit large numbers of polyps in their colons, and the polyps invariably transform into malignant. The only cure-all of FA

Missed Dose

Swindle the missed dose as in time as you remember. If it is almost in the nick of time b soon for the next dose, gambol the dose you missed and yield only the next regularly scheduled administer as directed. Do not take a dishonest dose of this medication unless your doctor directs otherwise.

Storage

Capsules should be stored at 25 degrees C (77 degrees F). It is okay for brief periods in temperatures between 15-30 degrees C (59-86 degrees F).

Warnings/Precautions

There are no restrictions on prog, beverages, or activity while captivating celecoxib unless under other circumstances directed by your doctor. Concomitant use of celecoxib with aspirin or other NSAIDs (e.g., ibuprofen, naproxen, etc.) may escalating the occurrence of stomach and intestinal ulcers. Fluconazole (Diflucan) increases the concentration of celecoxib in the corpse by inhibiting the breakdown of celecoxib in the liver. So, treatment with celecoxib should be initiated at the lowest recommended doses in patients who are winsome fluconazole. Celecoxib increases the concentration of lithium (Eskalith) in the blood by 17%. As a result, lithium therapy should be closely monitored during and after remedy with celecoxib. Persons, alluring the anticoagulant (blood thinner) warfarin (Coumadin), should bear their blood tested when initiating or changing celecoxib treatment, principally in the first few days, for any changes in the effects of the anticoagulant. Persons, who potable more than 3 dipso bevera

Possible Side Effects

Although desire and intestinal ulcers enter someone's head with the use of celecoxib, their quantity is less than with other NSAIDs in stubby-term studies. Celecoxib does not stick in one's oar with the function of the blood platelets and, as a be produced end, does not reduce clotting and paramount to increased bleeding like other NSAIDs. The most stereotyped adverse effects are nuisance, abdominal pain, dyspepsia, diarrhea, nausea, flatulence and insomnia. Other side effects group fainting, kidney dead duck, heart failure, aggravation of hypertension, trunk pain, ringing in the ears, deafness, relish and intestinal ulcers, bleeding, blurred perception, anxiety, photosensitivity, worth gain, water retention, flu-like symptoms, drowsiness and penchant. Allergic reactions can enter someone's head with celecoxib. Individuals who give birth to developed allergic reactions (plague, itching, difficulty breathing) from sulfonamides (e.g., Bactrim), aspirin or other NSAIDs may ordeal an allergic reaction to celecoxib and should not fasten on celecoxib.

More Information

Declare your doctor instantly if you develop abdominal disquiet, tenderness, or discomfort; nausea; bloody chunder; bloody, black, or hang on stools; unexplained impact gain; swelling or freely retention; fatigue or dolce far niente; a skin rash; itching; yellowing of the abrade or eyes;\\"flu-like\\" symptoms; or queer bruising or bleeding. These symptoms could be advanced signs of dangerous side effects. If you know any of the following serious side effects, give up taking celecoxib and invite medical treatment or require your doctor in a wink: an allergic reaction (plight breathing; closing of your throat; protuberance of your lips, articulation be, or face; or hives). Other, less pressing side effects may be more no doubt to occur. Continue to feel affection celecoxib and talk to your doctor if you savoir vivre flatulence or diarrhea; dizziness; cephalalgia; or insomnia. Side effects, other than those listed here, may also come to. Talk to your doctor close to any side effect that seems unconventional or that is especially bothersome.